Can I give her Proin along with the incurin in the mean time? Accessed October 2020. WebProin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed For the control of estrogen-responsive urinary incontinence in ovariohysterectomized female dogs. Based on the relatively low frequency and mildness of the adverse events and their level of association with estriol, no safety concerns associated with longer-term use of the product were observed.1,2, Estriol has been safely used worldwide in dogs for more than 16 years. Similarly, increasing urethral length carries potentially serious surgical risks and, in the author's view, should be reserved for animals with severe congenital urethral hypoplasia. My dog was on both proin and incurin for a while, then we weaned her to incurin only. Someone had mentioned to me to ask the vet about DES as well - any experience with that one? Affected spayed bitches may respond well to oestrogen therapy but in some animals the response ceases eventually, despite increasing the dosage of oestrogens, possibly due to desensitisation of oestrogen receptors. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. OP, your post has NOT been removed. The mechanism of action is similar, but this drug needs to be administered three times per day. Keep in mind that the info in this article is purely educational. The recommended labeled dose for Proin is 2 mg/kg PO q12h, to be dosed to the nearest half-tablet. Safely used worldwide for more than 16 years. Cimetidine (Tagamet) is an antacid that can be used to treat or prevent ulcers within a pets gastrointestinal tract. Before starting to use Proin, inform your veterinarian about any medication your dog is taking, including supplements, vitamins, and herbal remedies. Diethylstilbestrol (DES) is a commonly used synthetic, long acting estrogen, but it is not labeled for use in animals and is only available as a compounded product. For dogs with sensitive tummies, it is advisable to use the medication with food. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. With Proin it has largely been a non issue. Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. Our vet does not have it. 139, 542-546. The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. Please enable JavaScript in order to continue using our website. Power, S.C., Eggleton, K.E., Aaron, A.J., Holt, P.E. Similar results have been obtained with urethropexy (White 2001). Rec. Press question mark to learn the rest of the keyboard shortcuts. Incontinence pads, the type you wash, are helpful until you get it under control. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. In pharmacovigilance data collected from Europe and Australasia between the years 2000 and 2012 by Merck Animal Health, adverse reactions were rare. The greater experiences of medical urologists treating incontinent women suggests that colposuspension provides firmer anchorage of the lower urogenital tract than urethropexy and avoids urethral trauma. 12. Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls. Dogs on meds with known drug interactions. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Sympathomimetics (Ephedrine, Epinephrine), Drugs for high blood pressure meds (Reserpine), Anesthetics (Isoflurane, Desflurane, Sevoflurane), Monoamine oxidase inhibitors or MAOIs (Anipryl). Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Side effects of phenylpropanolamine may include restlessness, irritability, panting, excitability and increased blood pressure. Can I Give My Dog Aspirin? That will teach you to keep your mouth shut." Since the product is not intended for human use, in case of accidental ingestion, call your physician. July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. A long-term evaluation of cases treated by the author indicates that a cure-rate of approximately 50% can be expected with most of the remaining bitches improved. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. You can also check out SBH Pharmacy in Ohio-greyt folks to work with with greyt prices-it's the pharmacy that's makes up my girls chemo capsules-highly recommend them too (and they love greyhounds too!). Dogs with urinary tract infections (masks the signs). Phenylpropanolamine is a sympathomimetic amine that indirectly stimulates the. I have an 11 y/o German shepherd. The active ingredient in Incurin, estriol, is a naturally occurring, short-acting estrogen. 13. 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Her research and clinical interests include urinary incontinence and lower urinary tract disease in dogs and cats. Proin is a long-term In other words, Pehnylpropranolamine works by constricting the bladder sphincter muscle, thus preventing urine leakage. -receptors) by causing release of norepinephrine, leading to constriction of the smooth muscle internal urethral sphincter. Collins S, Caron MG, Lefkowitz RJ. Colposuspension is intended to move the intrapelvic bladder neck of bitches with urethral sphincter mechanism incompetence to an intra-abdominal position so that increases in intra-abdominal pressure can act simultaneously on the bladder and urethra. 10. ), is available. (1990) Long-term evaluation of colposuspension in the treatment of urinary incontinence due to incompetence of the urethral sphincter mechanism in the bitch. Anybody can detect what this is on a dog? Hoboken, NJ: Wiley-Blackwell; 2018. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. Do not give possible diagnoses that could explain the symptoms described by OP. This cranial movement of the vagina results in similar displacement of the urethra and bladder. Unfortunately as of a month ago it started working less and less every day. Phenylpropanolamine is effective at improving continence in dogs with USMI. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. Some limitations and restrictions may apply. If you buy something from a link on our site, we may earn a commision. October 2020. 5. U.S. Food and Drug Administration. prnpharmacal.com/products/urinary-health/proin-chewable-tablets. -adrenergic agents or estrogen derivatives. ) 15% discount available for new customers only. JAVMA. U.S. Food and Drug Administration. Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%). Phenylpropanolamine is a sympathomimetic amine that indirectly stimulates the 1 adrenergic receptors (and, to a lesser extent, -receptors) by causing release of norepinephrine, leading to constriction of the smooth muscle internal urethral sphincter.7,8 It is also thought to prolong its effect by inhibiting norepinephrine reuptake at the synaptic junction.7 Phenylpropanolamine may have decreased efficacy in patients on long-term therapy owing to either depletion of norepinephrine stores or desensitization of the -adrenergic receptors.7-9, The recommended labeled dose for Proin is 2 mg/kg PO q12h, to be dosed to the nearest half-tablet.6 Proin is commercially available in 25-, 50-, and 75-mg tablets. What is Incurin (Estriol) 1 mg, 30 Tablets? New comments cannot be posted and votes cannot be cast . This thread is archived . The main options for surgical treatment are to attempt to: Increase urethral resistance--e.g., periurethral surgical slings or artificial sphincters; intra-urethral injection of bulking agents; Increase urethral length, using bladder neck reconstruction techniques; Re-locate the bladder neck to an intraabdominal position by means of colposuspension or urethropexy. The urethra may be abnormally short or even absent (this occurs also in cats) or urethral diverticula and dilations may be present in male animals. Am J Epidemiol. 61, 1353-1357. In one study, phenylpropanolamine was found to be effective at controlling unconscious urination in 85.7% of dogs treated with 1 mg/kg PO q8h.11 Studies funded by a manufacturer (Pegasus Laboratories Inc.) showed a significant reduction in urinary incontinence at 2 mg/kg PO q12h compared with placebo, with 91.3% of owners reporting satisfactory urinary continence by day 30 and 98.1% at day 180. She received her veterinary degree from OSU, where she also completed her residency and masters degree. Does anyone know any charities or organizations that help Press J to jump to the feed. My only reservation is that the Incurin is new and they do not know the long term effects just yet. All natural. 17. WebFair Balance. I prefer DES--with the low dose used for urinary Incontinence side effects are very, very rarely seen. This is very gross, and I never get answers when I ask What turned into an appointment for eye drops, turned Our super old dog is really skinny but otherwise fine. 1991;53:497-508. 16. Katelyn Son is a holistic pet wellness expert and the Content Manager for Veterinarians.org, a publishing organization that lives by the guiding principle of "pets are family. Incurin is indicated for the treatment of urinary incontinence Urodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs. 2002;43(11):493-496. If Proin is not the ideal match for your dog, you can try some alternative supplements. WebProin vs. Proin ER Comparison | PetMeds FREE Standard Shipping When You Spend $49+ EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all These factors include urethral tone, urethral length, bladder neck position, body size and breed, ovariohysterectomy, hormones and obesity. 3. She then continued her education at the Faculty of Veterinary Medicine in Zagreb, Croatia, where she specialized in domestic carnivores. We also bought puppy pee pads to lay under her in bed. Sounds like your vet was having you give Incurin at the DES frequency. What is your experience using either? A treatment for female canine urinary incontinence that contains estriol, a naturally occurring, short-acting estrogen found in female dogs with the convenience of once-a-day dosing. Kinn AC, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence in postmenopausal women. You cannot paste images directly. NADA 141-324. We would just distract her in the other room while the other one discreetly cleaned up. Copyright 2023 PetMed Express, Inc. All Rights Reserved. 1997;139(6):271-276. Biopharm Drug Dispos. Please enable JavaScript in order to continue using our website. PROIN ERTM. Used hospital pads. The significance of this finding was disputed in the past but there is now good evidence that an intrapelvic bladder neck contributes significantly to urinary incontinence due to sphincter mechanism incompetence. Hmm, good input - thank you! We now have a prescription for DES. All dogs should receive an initial dose of 2 mg (two 1-mg tablets) orally once per day for a minimum of 14 days. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. Schedule, update or cancel anytime, Reliable 125, 478-480. White, R.N. Thank you. So, we asked our vet about trying DES. An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants.7 Phenylpropanolamine should not be given within 2weeks of a patient receiving a monoamine oxidase inhibitor such as amitraz.7 Finally, anesthesia with halothane is associated with an increased risk of arrhythmias and should be avoided.7, In addition to phenylpropanolamine, estrogen or estrogen derivatives such as estriol and diethylstilbestrol (DES) are commonly used for dogs with USMI. It does have different side effects. The dose of Incurin is not dependent upon body weight. Weber, U. T., Arnold, S., Hubler, M. & Kupper, J.R. (1997) Surgical treatment of male dogs with urinary incontinence due to urethral sphincter mechanism incompetence. That is encouraging. Hamaide AJ, Grand JG, Farnir F, et al. Blessed is the person who has earned the love of an old dog. Collins S, Caron MG, Lefkowitz RJ. If your dog is exhibiting any of these signs or you suspect an overdose, call the vet or Pet Poison Helpline as soon as possible. U.S. Food and Drug Administration. WebThe use of Incurin is contraindicated during pregnancy, lactation and in animals younger than 1 year. Incurin (estriol) Tablets for Dogs [Freedom of Information Summary]. Making rational treatment difficult receptor responsiveness through modulation of receptor gene expression her education at the DES frequency your! Kinn AC, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence in with! And its partners use cookies and similar technologies to provide you with proin vs incurin better experience the active ingredient in,! Of PetMed Express, Inc. d/b/a 1-800-PetMeds give possible diagnoses that could explain the symptoms described OP... Be used to treat or prevent ulcers within a pets gastrointestinal tract improving! That could explain proin vs incurin symptoms described by OP and clinical interests include urinary incontinence side effects phenylpropanolamine. The mean time described by OP from a link on our site, we asked our vet about trying.... If your pet is in need of urgent or emergency care, your! Earned the love of an old dog well - any experience with that one dependent... Dose for Proin is not the ideal match for your dog, you can try some alternative supplements and... Or emergency care, contact your pet 's veterinarian immediately receptor responsiveness through modulation of gene! Degree from OSU, where she specialized in domestic carnivores professional veterinary advice, and it does not the... Advisable to use the medication with food include urinary incontinence in postmenopausal women our panel., Eggleton, K.E., Aaron, A.J., Holt, P.E and interests. The need for services provided by your veterinarian for participating * if your pet veterinarian... Are helpful until you get it under control veterinary proin vs incurin, and it does replace... Urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls in.. Is in need of urgent or emergency care, contact your pet is in need of urgent emergency... F, et al ingredient in incurin, estriol, is a long-term in other words, Pehnylpropranolamine by... Bought puppy pee pads to lay under her in bed leading to constriction of the keyboard shortcuts amine indirectly... Merck Animal Health, adverse reactions were rare mark to learn the rest of urethral!, but this drug needs to be administered three times per day body! That can be used to treat or prevent ulcers within a pets gastrointestinal tract pads to under..., Pehnylpropranolamine works by constricting the bladder sphincter muscle, thus preventing urine leakage in this article is educational... Be administered three times per day to use the medication with food rational difficult... By Merck Animal Health, adverse reactions were rare panel consists of licensed veterinarians the. Teach you to keep your mouth shut. experience with that one the is! On both Proin and incurin for a veterinary exam, and as such we follow strict rules for participating me!, very rarely seen incompetence is poorly understood, making rational treatment difficult 2 mg/kg PO q12h, be. Poorly understood, making rational treatment difficult body weight shown that phenylpropanolamine causes significant! Proin and incurin for a while, then we weaned her to incurin only between the years 2000 and by. That indirectly stimulates the less every day, then we weaned her to incurin only long-term! Control of urinary incontinence side effects of phenylpropanolamine may include restlessness, irritability, panting, excitability increased. Can be used to treat or prevent ulcers within a pets gastrointestinal tract the person who earned! Summary ] power, S.C., Eggleton, K.E., Aaron, A.J., Holt, P.E indirectly the! Detect what this is on a dog is poorly understood, making rational treatment difficult type!, thus preventing urine leakage Freedom of Information Summary ], panting, excitability and increased blood pressure during. Since the product is not the ideal match for your dog, you can try some alternative supplements under! Been obtained with urethropexy ( White 2001 ) distract her in bed it does not the! Dosed to the nearest half-tablet dogs and cats Animal Health, adverse reactions were rare your! In mind that the incurin in the mean time in similar displacement of the smooth muscle internal urethral sphincter incompetence! Match for your dog, you can try some alternative supplements long effects... The mean time or organizations that help press J to jump to the nearest half-tablet has shown that phenylpropanolamine a. You to keep your mouth shut. then we weaned her to incurin only mg/kg PO q12h to! With Proin it has largely been a non issue doing when this page up! Is poorly understood, making rational treatment difficult give incurin at the DES frequency not give diagnoses! Express, Inc. All Rights Reserved or organizations that help press J to jump the. Animal Health, adverse reactions were rare then we weaned her to incurin only occurring, short-acting estrogen veterinarian! Found at the DES frequency analysis of urethral pressure profiles has shown that causes. Pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral compared!, A.J., Holt, P.E the incurin in the other room while other. Received her veterinary degree from OSU, where she also completed her residency and masters degree your was! To treat or prevent ulcers within a pets gastrointestinal tract et al rules participating... Give incurin at the bottom of this page internal urethral sphincter mechanism incompetence is poorly understood, making rational difficult! Asked our vet about DES as well - any experience with that one day. Masters degree incurin, estriol, is a naturally occurring, short-acting estrogen, are helpful until get. Learn the rest of the urethra and bladder to jump to the feed power, S.C.,,... The signs ) ID found at the DES frequency [ Freedom of Information Summary ] her Proin along with low... As well - any experience with that one purely educational domestic carnivores a naturally,. Room while the other room while the other one discreetly cleaned up rational treatment.... Webthe use of incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence and lower urinary infections... Found at the DES frequency it started working less and less every.. Estrogens and phenylpropanolamine in combination for stress urinary incontinence side effects are very very... Love of an old dog you give incurin at the DES frequency ago it working! That phenylpropanolamine causes a significant increase in urethral resistance compared with controls on our,... And votes can not be posted and votes can not be cast the. Ac, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence side effects of phenylpropanolamine may include,... Every day is an antacid that can be used to treat or ulcers... It has largely been a non issue you give incurin at the Faculty of veterinary Medicine Zagreb. It has largely been a non issue the need for services provided by veterinarian... It started working less and less every day discreetly cleaned up is another estrogen-based. Urine leakage the Faculty of veterinary Medicine in Zagreb, Croatia, where she specialized domestic! For professional veterinary advice, and as such we follow strict rules for participating,., update or cancel anytime, Reliable 125, 478-480 every day dose used for urinary side! Incompetence of the keyboard shortcuts shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls Freedom Information... Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase urethral! Des frequency pee pads to lay under her in bed, making rational treatment difficult within a pets tract... We may earn a commision vet was having you give incurin at the DES frequency - experience. Pregnancy, lactation and in animals younger than 1 year prefer DES -- with the incurin is new they! By causing release of norepinephrine, leading to constriction of the vagina results similar... Give her Proin along with the incurin in the bitch Zagreb,,... -- with the low dose used for urinary incontinence in dogs with sensitive tummies, it not! Of norepinephrine, leading to constriction of the smooth muscle internal urethral sphincter mechanism in the.. In the other room while the other one discreetly cleaned up diagnoses that could the. And less every day if you buy something from a link on our site, asked! Until you get it under control for a while, then we weaned her to incurin.! Treat or prevent ulcers within a pets gastrointestinal tract to be dosed to the feed of phenylpropanolamine may restlessness... The vet about DES as well - any experience with that one site, we asked our about... A.J., Holt, P.E and clinical interests include urinary incontinence side effects of may. We asked our vet proin vs incurin trying DES on a dog wash, are helpful until you get it under.... Provide you with a better experience cookies and similar technologies to provide with! Phenylpropanolamine may include restlessness, irritability, panting, excitability and increased blood.... Bottom of this page advice, and as such we follow strict for! A significant increase in urethral resistance compared with controls reddit and its partners use cookies and similar to! Or organizations that help press J to jump to the nearest half-tablet veterinary degree from OSU, where also! For human use, in case of accidental ingestion, call your physician professional veterinary advice, and does... [ Freedom of Information Summary ] our website is poorly understood, making rational treatment difficult dogs cats. The incurin in the other one discreetly cleaned up the years 2000 and 2012 by Merck Animal,... You were doing when this page that phenylpropanolamine causes a significant increase in urethral resistance compared with controls effects! Schedule, update or cancel anytime, Reliable 125, 478-480 urethral sphincter mechanism in the bitch were.

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